94SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME CINNOLINE DERIVATIVESThe review of literature showed that cinnoline derivatives were found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. Imidazole can be found in many other drugs such as dacarbazine, metronidazole, cimetidine, flumazenil, thyroliberin, methimazole, pilocarpine and etomidate which are used as antineoplastic antibiotic, antiulcerative, benzodiazepine antagonist, prohormone, antihyperthyroid, muscarinic receptor.In the substituted Cinnoline Imidazole series, the compounds which are halogen mainly Chloro Substituted were showed potent antibacterial, anti-inflammatory and anti-fungal activity than other compounds. However Methyl substituted compound also showed more potent antimicrobial activity and anti-inflammatory activity.pankajmishramph@gmail.comResearch522015Cinnoline,Imidazole,Anti-inflammatory activityMishra Pankaj, Saxena Vikas,Kesheri Minu,Saxena AbhishekDepartment of Pharmaceutical Chemistry, Shridhar University Pilani, Rajasthan, India.,Department of Pharmaceutical Chemistry, Shridhar University Pilani, Rajasthan, India.,Department of Pharmaceutical Chemistry, Shridhar University Pilani, Rajasthan, India.,Department of Pharmaceutical Chemistry, Shridhar University Pilani, Rajasthan, India.