81EVALUATION OF THE ANTICONVULSANT ACTIVITY OF OMEPRAZOLE IN COMPARISON WITH VALPROATE IN ALBINO RATSThis study was conducted to evaluate the potential of omeprazole as an anti-epileptic drug and compare it with currently used drug such as Valproate using Pentylenetetrazole (PTZ) induced convulsion model. Randomized, Prospective, controlled, open labelled study using Healthy Albino Sprague-Dawley rats. All animals were randomly divided into 4 groups and each group comprises 6 rats. Study Drugs & Dosage for Pentylenetetrazole (PTZ) Model are for control: Distilled water, Study drug: Omeprazole: 0.5 mg/kg & 1 mg/kg, Standard drug: Valproate: 200 mg/kg and Pentylenetetrazole: 48 mg/kg. Both the doses of Omeprazole (0.5 mg/kg and 1 mg/kg) increases in the time of onset of first clonic convulsion, and reduce duration of clonic convulsion and duration of post-ictal phase and appears to be effective in protecting the animal against seizure induced by Pentylenetetrazole (PTZ) model. Have efficacy comparable to Valproate. Omeprazole at the doses (0.5 mg/kg and 1 mg/kg) has an anticonvulsant activity in Pentylenetetrazole (PTZ) model.ramanand004@gmail.comResearch512015Omeprazole,Pentylenetetrazole,ValproateRamanand J Patil,S.B.Patel,Abhijeet Joshi,Madhukar GaikwadAssistant Professor, Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune – 411041, Maharashtra, India., Professor and Head, Department of Pharmacology, Grant Govt. Medical College & Sir J J Group of Hospitals, Mumbai – 400008, Maharashtra, India,Assistant Professor, Department of Pharmacology, Grant Govt. Medical College & Sir J J Group of Hospitals, Mumbai – 400008, Maharashtra, India,Assistant Professor, Department of General Medicine, Grant Govt. Medical College & Sir J J Group of Hospitals, Mumbai – 400008, Maharashtra, India