57EVALUATION OF ANTIMICROBIAL ACTIVITY OF CATUNAREGUM SPINOSAThis study was carried out with an objective to evaluate the antibacterial and antifungal potential of methanolic extract of Catunaregum spinosa (MECS). Antibacterial activity of MECS was carried out against three Gram negative bacteria – Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa and two Gram positive bacteria – Bacillus Subtilis and Staphylococcus aureus. The antifungal activity of the extracts was evaluated on two common pathogenic fungi – Aspergillus niger and Candida albicans. The testing was done by the agar plate method. Zones of inhibition of extracts were compared with that of standard Chloramphenicol for antibacterial activity and Nystatin for antifungal activity. The extracts showed antibacterial and antifungal activities comparable with that of standard against the organisms tested. The results showed that the inhibition of the bacterial growth was more pronounced on E.coli and S. aureus as compared to the other tested organisms. Both the extracts showed the antifungal activity against C. albicans.chitrampharm@gmail.comResearch422014Antibacterial,Antifungal,Catunaregum spinosaA. Chitra,N. Senthilkumar,M. Asraf Ali Sunrise University, Alwar, India.,JKKMMRF’s College of Pharmacy, B. Komarapalayam, Tamilnadu, India., Sunrise University, Alwar, India.