43CNS ACTIVITY OF METHANOLIC EXTRACT OF KIGELIA AFRICANA (LAM) IN EXPERIMENTAL ANIMALSThe aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Kigelia africana (Bignoniaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 400 mg/kg. The results of the present study indicates that the methanolic extract of Kigelia africana leaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.rkhemamalini@gmail.comResearch412014Kigelia africana,Behavioural,Muscle coordination,Anxiolytic activitiesShalini K,Kavya Sree K,Vijusha M,Rajani A, Hemamalini KTeegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India.,Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India.,Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India.,Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Hyderabad, Andhra Pradesh, India,Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India.