7CEREBRO-PROTECTIVE EFFECT OF DECALEPIS HAMILTONII AGAINST GLOBAL MODEL OF ISCHEMIA IN RATSTraditionally, the Root of Decalepis hamiltoni is used for various diseases, including blood and neuronal disorders. To evaluate the cerebroprotective effect of Ethanol extract of Root of Decalepis hamiltonii (EEDH) against the global model of ischemia in rats. In the present study, the animals were pre-treated with EEDH for a period of 1week (250 and 500 mg/kg) p.o. The animals were anaesthetized with thiopentone sodium (45mg/kg) and stroke was induced by Bilateral Carotid Artery Occlusion (BCAO) for defined period with aneurism clamps placed on both arteries and later (10 minutes) clamps were removed to allow reperfusion and animals were then returned to their cages. After 24 hours of reperfusion, the animal behaviors were evaluated by various methods such as behaviour pattern, Juvenile recognition, Motor activity, rotar rod test, Morris water maze test in stroke induced animals. The treatment was continued for another week after surgery with EEDH. The present studies suggest that, there was a decrease in the escape latency in water maze in stroke induced (negative control) group. The group treated with 250mg/kg and 500 mg/kg EEDH showed significant (P<0.01) improvement in the behaviour pattern, and spatial learning, which was confirmed in trial sessions in water maze test when compared with the negative control group. In conclusion, ethanol extract of Root of Decalepis hamiltonii produced cerebroprotective effects in global cerebral ischemia as evident from reduction in behavioral score, hyper locomotion and neuronal damagesrirampharmar@gmail.comResearch212012Root of Decalepis hamiltonii,Bilateral Carotid Artery Occlusion (BCAO), global cerebral ischemiaN.Sriram,S. Shahid Mohammed,S.Sakthivel,S.RavichandranSmt.Sarojini Ramulamma college of pharmacy, Mahabubnagar, Andhra Pradesh, India.,Seven Hills college of pharmacy, Tirupathi, Andhra Pradesh, India., PRRM College of pharmacy, Kadapa, Andhra Pradesh, India.,PSG College of pharmacy, Coimbatore, Tamil Nadu, India