33PRODRUG APPROACH - A REVIEWProdrug design is a choice of approach in solving many of the stability, solubility, permeability and targeting problems that plague drug discovery and development. The prodrug approach has the ability to keep promising new drug candidates alive through development, and improving the safety and efficacy of existing drug products. It is a very fruitful area of research and its introduction in human therapy has given successful results in improving the clinical and therapeutic effectiveness of drugs suffering from undesirable side-effects. About 14% of drugs approved worldwide can be classified as prodrugs. The present article takes a review of introduction and applications of prodrug design in various areas of drug development by overcoming side-effects of existing drugs.ankithpharmaline0002@gmail.comReview322013Prodrug,Carrier,Pro-moiety,Parent drug,Bioprecursor, Mutual ProdrugAnkith Kumar Reddy B,Subhashis Debnath,M. Niranjan BabuDepartment of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India.,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India.,Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh- 517 561, India.