263INVESTIGATING THE ANTIDIABETIC POTENTIAL OF INDIGOFERAASTRAGALINAINSTZ + NICOTINAMIDEINDUCED TYPE II DIABTETES IN ADULT ALBINO WISTAR RATSThe global burden of diabetes mellitus (DM), particularly Type 2 DM (T2DM), continues to escalate, highlighting a critical need for safe, effective, and affordable therapeutic interventions. This study was designed to investigate the multifaceted antidiabetic and organ-protective potential of an ethanol extract of Indigoferaastragalina (EEIA) in a Streptozotocin (STZ)- Nicotinamide (NIC)-induced T2DM rat model. The methodology included a comprehensive phytochemical analysis of the extract, an acute oral toxicity study, and a 15-day in vivo assessment of its effects on various metabolic and histopathological parameters. Wistar rats were divided into a normal control group, a diabetic control group, two EEIA treatment groups (250 and 500 mg/kg), and a standard drug group (glibenclamide, 0.25 mg/kg). Phytochemical screening of the EEIA confirmed the presence of a diverse range of bioactive compounds, including glycosides, flavonoids, alkaloids, terpenoids, and tannins. A critical finding from the histopathological analysis of the pancreas was the observed dose-dependent regenerative effect on the pancreatic islets. In conclusion, the findings of this study provide robust scientific validation for the traditional use of Indigoferaastragalina and underscore its promise as a multi-targeted therapeutic agent for the comprehensive management of T2DMjothies82@gmail.comResearch1522025T2DM- Type 2 diabetes mellitus, Ethanol Extract of IndigoferaAstragalina (EEIA), Streptozotocin (STZ), Nicotinamide (NIC)M Bhavya Sree, Bhaskar Reddy K, Jothieswari D*, K JeevanaSri Venkateswara College of Pharmacy, RVS Nagar, Tirupati Main Road, Chittoor - 517127, Andra Pradesh, India