241EXPLORING THE ANTI-INFLAMMATORY EFFICACY OF PAVONIA PROCUMBENS METHANOL EXTRACT IN PRECLINICAL MODELSNatural products have long been a cornerstone of medicine, with their relevance persisting into modern pharmacology, especially for addressing chronic and inflammatory conditions. This study evaluates the anti-inflammatory potential of the methanol extract of Pavonia procumbens leaves using the formalin-induced paw edema model in Swiss albino mice. The phytochemical screening revealed significant phenolic content (243.94 ± 53.28 mg/g), known for modulating inflammatory pathways. Acute toxicity studies demonstrated the extract’s safety at a dose of 2000 mg/kg with no observed adverse effects. Anti-inflammatory activity was assessed in two doses (200 mg/kg and 400 mg/kg), compared against diclofenac (10 mg/kg) as a standard. The extract showed a dose-dependent reduction in paw edema, with the higher dose achieving a 61.72 ± 0.19% inhibition of edema at 240 minutes, comparable to diclofenac’s 64.84 ± 0.13%. The anti-inflammatory effects are attributed to bioactive compounds such as phenolics, flavonoids, and tannins, which likely inhibit pro-inflammatory mediators like prostaglandins, cytokines, and nitric oxide. These findings highlight the therapeutic potential of Pavonia procumbens as a natural alternative to synthetic antiinflammatory drugs, offering comparable efficacy with fewer side effects. Further research is warranted to elucidate the extract’s molecular mechanisms and pharmacokinetics to ensure clinical applicability. With continued study, Pavonia procumbens could become a valuable addition to plant-based anti-inflammatory therapiesjothies82@gmail.comResearch1412024Pavonia procumbens, anti-inflammatory, phenolic content, paw edema, natural therapeuticsDr. Jothieswari D,Dr. Jothieswari DProfessor and Principal, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andra Pradesh, India,Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andra Pradesh, India.