235CORRELATION BETWEEN SURGICAL PLETH INDEX AND STRESS HORMONES IN GENERAL ANESTHESIADuring general anesthesia, the Surgical Pleth Index (SPI) showed a moderate correlation with stress hormone levels, while no such relationship was observed during consciousness. Additionally, SPI values reliably predicted adrenocorticotropic hormone (ACTH) levels. This highlights SPI's potential as a predictor of stress hormone dynamics under anesthesia.Samala@gmail.comResearch922019Surgical Pleth Index (SPI), General anesthesia, Stress hormones, Target-controlled infusion, Elective surgery.Dr Chaitanya Vatluri,Dr Samala Kartika BalajiAssistant Professor, Department of Anaesthesiology, Katuri Medical College & Hospital, Chinakondrupadu, Guntur, India,Assistant Professor, Department of Anaesthesiology, Katuri Medical College & Hospital, Chinakondrupadu, Guntur, India