218ARTEMISININ-BASED COMBINATION THERAPY IS MORE EFFECTIVE FOR THE TREATMENT OF INFECTIOUS MALARIAUsing data from a secondary and tertiary hospital, this study aimed to describe the pattern of outpatient anti-malarial drug prescribing as well as assessing compliance with the National Anti-malarial Treatment Guideline (ATG). Two health facilities in 2022 were audited for six months for anti-malarial prescription records. The national antimalarial treatment guidelines were assessed using semi-structured questionnaires that were administered to doctors and pharmacists. A combination therapy based on artemisinin was the most frequently prescribed antimalarial. Artemether-lumafantrine accounted for 55.78% of the total prescriptions out of ACTs, which made up 80.56%. As a result, only 36.7% of tertiary hospital patients adherer to the drugs indicated by national guideline and 68.5 % of secondary hospital patients adhere to the drugs suggested by the guideline within the DU ninety per cent. Hospitals understudied failed to adhere to standard practice of prescribing generic drugs. Among doctors and pharmacists, 81.25% were aware of the ATG. According to the guideline, 12.2% of doctors and 53.3% of pharmacists were unable to correctly list the drugs. When treated with oral quinine, adolescents aged 0 - 3 months were preferred to be treated with amodiaquine. Artemisinin-based combination therapy was more frequently used in this study than previous studies for treating uncomplicated malaria. Additionally, this study concludes that health professionals need periodic in-service quality assurance to ensure compliance with and a thorough understanding of clinical guidelineszionnikki@gmail.comResearch1312023Anti-malaria,Artemisinin,Clinical guidelinesNikitha D,Pallavi A,Manasa N,Nazia Begum, Akila CRKLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India,KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India,KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India,KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India