216LINEZOLID IS AN OXACILLIN TB MEDICATION THAT IS EFFECTIVE, SAFE, OR INEXPENSIVE Linezolid has been recognised as an effective medicine for treating people with tuberculosis multidrug-resistant (TB). On either hand, cost and safety are key concerns. A 600-mg linezolid pill costs as little as a dollar in India, This is far less expensive than third-line services antibiotic medications. Methods: In India, A prospective research was conducted on Patients with MDR-TB were divided into two groups: 16 with XDR-TB and 13 with MDR-TB with resistant microorganisms but injectable sensitivity. Linezolid is a fluoroquinolone that comes in the form of an injectable medication antibiotics were administered to all of the patients additional medicines on a daily basis without supervision. Results:An minimum of six antimycobacterial medicines were given to the patients. Capreomycin, associated oral, levofloxacin, and layers acid were used by 41.4 %, 58.6%, 41.4 %, and 79.3% of the patients, respectively. Out of 29 participants, 89.7% had a positive sputum smear with cultured conversion; 72.4 % had a positive intermediate 10.3 percent perished, 6.8 percent lost, and 10.3 percent defaulted as a result. Three patients (10.3 percent) had to discontinue taking linezolid because to side effects. The treatment outcomes of 16 XDR-TB children were similar to those of the remaining 13 MDR-TB patients. Conclusions: In individuals with Linezolid is an effective, affordable, and relatively safe drug for MDR-TB, many with established XDR-TBRanjith@gmail.comResearch1022020Extensively Drug-Resistant, LinezolidRanjith Kumar SreeramaAssociate Professor, Department of General Medicine, Tagore Medical College & Hospital, Chennai - 600127