170A COMPARATIVE STUDY ON THE HYPOGLYCAEMIC EFFECT OF Pterocarpus Marsupium SEED EXTRACT IN ALLOXAN INDUCED AND GABAPENTIN INDUCED DIABETES IN EPILEPTIC RATSAIM: Diabetes mellitus is a metabolic disorder, which is affecting the population of the developed and developing countries. Diabetes contains a number of chronic complications like nephropathy, neuropathy, retinopathy and cardiovascular diseases. Pterocarpus marsupium is a medicinal plant used in Ayurvedic system of medicine to control blood sugar. The aim of the study is to evaluate the antidiabetic activity of Pterocarpus marsupium seed extract on alloxan induced diabetes and compare the results with gabapentin induced diabetes in epileptic rats. MATERIALS AND METHODS: The present work was designed to evaluate the anti hyperglycemic activity of Pterocarpus marsupium seed extract (100mg/kg and 200mg/kg) on alloxan induced diabetes and gabapentin induced diabetes in epileptic rats. Blood glucose level, serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were evaluated in alloxan and gabapentin induced diabetic rats. The results of the test drug were compared with the standard drug. RESULT: Rats treated with ethanolic seed extract of Pterocarpus marsupium at 100mg/kg and 200 mg/kg had significantly reduced the blood glucose level. The fall in blood sugar level produced by Pterocarpus marsupium was more effective in gabapentin induced diabetes compared to the standard drug. Pterocarpus marsupium shows significant decrease in triglycerides levels, serum cholesterol levels, LDL levels and increased HDL levels, total protein levels in both alloxan induced and gabapentin induced diabetic models compared to the disease control group. CONCLUSION: In conclusion, the ethanolic seed extract of Pterocarpus marsupium has potential hypoglycaemic action and hypolipidaemic action in alloxan induced and gabapentin induced diabetic rats and more effective in reducing blood sugar level in gabapentin induced diabetes in epileptic rats compared to the standard drug.sivanageshmekala@yahoo.comResearch1022020Pterocarpus marsupium,Diabetes mellitus,Alloxan,Gabapentin,MetforminSivanageswararao Mekala,Salum Seif Salum Mchenga,Saravanan RLecturer in Pharmacology and Head of Allied Health Sciences, School of Health and Medical Sciences, The State University of Zanzibar, Tanzania.,Lecturer in Pathology and Dean, School of Health and Medical Sciences, The State University of Zanzibar, Tanzania.,Associate Professor and Head, Department of Pharmacology, RVS Dental College and Hospital, Coimbatore, Tamilnadu, India.