150COMPARATIVE STUDY OF THE EFFICACY OF NIFEDIPINE AND ISOXSUPRINE AS TOCOLYTICS FOR PRETERM LABOURBackground: A retrospective study was conducted to compare the efficacy of nifedipine against isoxsuprine in preventing preterm labour and also to evaluate maternal side effects and neonatal outcome. Methods: This was a retrospective comparative study done at BRIMS Teaching Hospital Bidar by scrutinizing the in patients case sheets from Medical Record Department, from June 2015 to Aug 2015. 100 antenatal women with gestational age between 28 to 36 weeks fulfilling the inclusion criteria and who received Nifidipine and Isoxsuprine were compared. Results: Groups were compared with mean prolongation of delivery, side effects, neonatal outcome, parity, cervical effacements. It was found that Nifedipine was twice more effective than isoxsuprine hydrochloride as a uterine tocolytic agent while side effects were comparable with fewer side effects in nifedipine group in comparison to Isoxsuprine. Neonatal outcome was also better with nifedipine in comparison to isoxsuprine. Conclusions: The present study found that nifedipine was better tocolytic agent with lesser side effects and better tolerability as compared to isoxsuprine.drsavitha96@rediffmail.comResearch912019Preterm labor,Tocolytics,Nifedipine,Isoxsuprine hydrochloride,RitodrineSavitha. A,Sarita. H Senior Resident, Department of OBG, Bidar Institute of Medical Sciences, Bidar, Karnataka.,Associate professor, Department of OBG, Bidar Institute of Medical Sciences, Bidar, Karnataka.