154EVALUATION OF IMMUNOMODULATORY ACTIVITY OF THE ETHANOLIC EXTRACT OF EVOLVULUS ALSINOIDESEvolvulus alsinoidesa plant showed powerful anti‑cancer activity in various cancer cell lines by stimulating macrophage cells which plays a central role in the immune system. The present study was conducted to evaluate the immunomodulatory activity of ethanolic extract of aerial parts of Evolvulus alsinoides (EEEA). In the current study, neutrophil adhesion test, carbon clearance test, haemagglutinating antibody titre test, delayed‑type hypersensitivity reaction test and cyclophosphamide‑induced Immunosuppression test was performed. EEEA 200 and 400 mg/kg oral dose were selected for the study after conducting the acute dose toxicity study.All the studies were performed in Swiss albino mice. EEEA showed a dose dependent increase in the neutrophil adhesion to the nylon fibres, produced a significant increase in the phagocytic index in carbon clearance test and a significant protection against cyclophosphamide‑induced immunosuppression. Moreover both doses of EEEA produced an increase in the circulating serum immunoglobulins in haemagglutinating antibody titre test along with an increase in the foot pad edema in delayed‑type hypersensitivity reaction test. From the above findings it is concluded that EEEA has the ability to modulate both humoral and cell‑mediated immunitym.ragukarpagam@gmail.comResearch922019Cellmediated immunity,Humoral immunity,Immunomodulation,Evolvulus alsinoidesR.Srinivasan,R.Srinivasan,Rahothraj M,Manikandan T,Sakthivel V,Randhale vijayakumar nagesh,Karthick KPallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.,Pallavan Pharmacy College, Kolivakkam, Kanchipuram, Tamil Nadu 631502, India.