123ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF KEDROSTIS FOETIDISSIMA IN MICEDiarrhoea is a condition of having three or more loose or liquid stools per day. It is a common cause of death in Third World Countries and the second most known cause of children deaths worldwide. In many developing countries, a large proportion of the population relies on traditional practitioners and their armamentarium of medicinal plants in order to meet health care needs. The oaim of the study is to evaluate the anti-diarrhoeal activity of ethanolic leaf extract of Kedrostis foetidissima against experimentally induced diarrhoea in laboratory animals. Swiss albino mice were used in faecal put model and castor oil induced diarrhoea models. For above two models, the animals were divided into 4 groups of six animals each. Group I served as control received CMC solution, Group II and III were administered with 200 and 400 mg/kg of ethanolic leaf extract of Kedrostis foetidissima respectively. Group IV served as reference control, received 5mg/kg of Loperamide. The result showed that, in measurement of faecal output there was significant decrease in feacal out was observed with Kedrostis foetidissima and in castor oil induced diarrhoea test, both the doses of Kedrostis foetidissima reduced the number of diarrhoealFrom the above it was concluded that, ethanolic leaf extract of Kedrostis foetidissima exhibited antidiarrhoeal activity in animal models.sengt@rediffmail.comResearch622016Kedrostis foetidissima,Anti-diarrhoea,Castor Oil and AppakovaiAnjana Yogesh,Latha M,SaravanaBalaji MD,Premlal KR,Vinod Mony,Sivaprakash VDepartment of Periodontics,KGF College of Dental Sciences & Hospitals, BEML Nagar, Kolar Gold Fields, Kolar, Karnataka, India.,Department of Oral Pathology, KGF College of Dental Sciences & Hospitals, BEML Nagar, Kolar Gold Fields, Kolar, Karnataka, India., Department of Periodontics, RVS Dental College & Hospital, Coimbatore, Tamilnadu, India.,Division of Oral Pathology & Microbiology, Indira Gandhi Institute of Dental Science, Sri Balaji Vidyapeeth University, Puducherry, India.,Division of Oral Pathology, PMS College of Dental Science & Research, Trivandrum, Kerala, India.,Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamilnadu, India