129EVALUATION OF ANTI-EPILEPTIC ACTIVITY OF METHANOLIC EXTRACT OF Stereospermum chelonoides (BIGNONEACEAE)The present study is an investigation of anti-epileptic activity of Stereospermum chelonoides (Family- Bignoneaceae) is a well-known plant which is being used in Indian traditional medicines for treating epilepsy, diarrhoea, dysentery, cholera and ulcers. The methanol extract of Stereospermum chelonoides (MESC) was subjected to acute toxicity and then screened for anti-epileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was nontoxic up to the recommended dose 2000 mg/kg. p.o. Animals were treated with EESC at doses of 200 and 400 mg/kg body weight. Study results showed, the mean duration of extensor phase of treated groups reduced significant level than compared to control group. In pentylenetetrazole induced seizure model, onset of myoclonic spasm and clonic convulsion was delayed in the EESC treated groups. EESC showed anti-epileptic activity against MES and PTZ animal models.saravanacology@gmail.comResearch712017Anti-epileptic activity,Stereospermum chelonoides,Maximal Electroshock (MES),Pentylenetetrazole (PTZ)A. Saravanakumar,G. Ashok,G. Hemambar,K. Shambhavi,Tshering Dema BlonDepartment of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Tirupathi Road, Chittoor-517127, Andhra Pradesh, India.,Department of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Tirupathi Road, Chittoor-517127, Andhra Pradesh, India.,Department of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Tirupathi Road, Chittoor-517127, Andhra Pradesh, India.,Department of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Tirupathi Road, Chittoor-517127, Andhra Pradesh, India.,Department of Pharmacology, Sri Venkateswara College of Pharmacy, R.V.S. Nagar, Tirupathi Road, Chittoor-517127, Andhra Pradesh, India.