124ANTIEPILEPTIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF THALICTRUM FOLIOLOSUM ON MAXIMAL ELECTROSHOCK (MES) AND PENTYLENETETRAZOLE (PTZ) INDUCED SEIZURE IN RATSThe present study was an attempt to investigate of antiepileptic activity of hydroethanolic extract of Thalictrum foliolosum (HEETF) belonging Ranuculaceae family. T. foliolosum is well known plant which is being used to Indian traditional medicine for treating different aliments like malaria, epilepsy, neurotonic and jaundice etc. Wistar albinoRats either sex (n=6), the animals treated with different doses of HEETF extracts 300, 400, 500 mg/kg ip. Injection of Diazepam 4mg/kg ip as positive control, whereas other group injected vehicle as normal saline 1ml/100gm for 7th days. On the 7th day administered PTZ 110mg/kg ip were injected. Determine behavioral responses of all animals when PTZ were administered evaluated antiepileptic response using following criteria, like onset of convulsion, duration of convulsion, protection against GTCS and mortality. Effects of HEETF on MES Induced Epilepsy, at doses of 300, 400 and 500 mg/kg were protect animals from seizures and significantly 300 mg/kg, 400 mg/kg and 500 mg/kg have shown 49.8%, 66.4% and 83% protection respectively. Intraperitoneal administration of lower dose of hydroethanolic extract of T. foliolosum (200 mg/kg) had no potent effects on generalized tonic-clonic seizures (GTCS), while injection of 300 & 400 mg/kg caused significant increase in GTCS latencies (p<0.01). In this study diazepam, (4 mg/kg) 1 hrs prior to PTZ, significantly increased GTCS latency. T. foliolosum at test doses protection against mortality following PTZ administration. Experimental finding reveal that hydroethanolic extract of T. foliolosum could be a useful protective antiepileptic agent. However further study still needed to be causes on exposure of extract to human beings.akhi.kotiyal482@gmail.comResearch712017Pentylenetetrazole,Phenytoin,Mamira,Thalictrum foliolosum,Antiepileptic,Pilijari,DiazepamAkhilesh,Neeraj Kumar,Manoj BishtDevsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur, Uttarakhand, India.,Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur, Uttarakhand, India.,Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur, Uttarakhand, India.