111ANTI-HYPERGLYCEMIC EFFECT OF HYDROALCOHOLIC EXTRACT OF IPOMOEA PES-TIGRIDIS LINN IN TYPE-II DIABETES AND THEIR EFFECTS ON KEYMETABOLIC ENZYMES INVOLVED IN CARBOHYDRATE METABOLISMThe antihyperglycemic effect of hydroalcoholic extracts of (Ipomoea Pes-tigridis) was evaluated in diabetic rats using Alloxan monohydrate(150mg/kg) as diabetogenic agents for pilot study (4 weeks)so as to assess their effect in mild (plasma sugar more than 160mg/dl)diabetes mellitus. In the pilot study maximum reduction of 67.2% and 66.3 % glucose levels was observed in animals receiving 200mg/kg and 400mg/kg per day of Hydro alcoholic extracts of (Ipomoea Pestigridis) after 4 weeks of treatment, respectively. The alteration in hepatic glycogen content and hepatic glucokinase, hexokinase and glucose-6- phosphate levels in diabetic rats were partially restored by Hydro alcoholic extracts of (Ipomoea Pes-tigridis).annaarulmed@yahoo.co.inResearch612016Hydro alcoholic extracts of Ipomoea pes-tigridis,Glycogen content,Glucokinase,Hexokinase,Glucose-6- phosphate,Diabetes mellitusPeter Thanislas,Ajithadas Aruna,Parameswari RathnakumarInstitute of Pharmacology, Madurai Medical College, Madurai-625020, Tamilnadu, India,Joint Directorate of Medical Education (Pharmacy), Kilpauk, Chennai-600 003, Tamilnadu, India,Institute of Pharmacology, Madurai Medical College, Madurai-625020, Tamilnadu, India