Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, Warangal, A.P., India

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, Warangal, A.P., India

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, Warangal, A.P., India

Pharmacology Research Division, Vaagdevi Institute of Pharmaceutical Sciences, Bollikunta, Warangal, A.P., India
Ageratum conyzoides ,Hepatoprotective ,CCl4 ,Silymarin ,Hepatotoxicity ,

To investigate the hepatoprotective activity and acute oral toxicity of methanolic extract of aerial parts of Ageratum conyzoides (MEAL) in male Wistar albino rats by using CCl4 induced hepatoptoxicity. The MEAL at doses of 200 and 400mg/kg, p.o and the standard drug Silymarin (100mg/kg, p.o) were administered three times at 12h intervals and then CCl 4 (1ml/kg) was administered to all the groups except normal control for 2 days. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, ALP, γ-GT, TP and total bilirubin along with histopathological studies were observed after 36h of CCl4 treatment. The MEAL at the doses of 200 and 400mg/kg inhibited CCl4 induced liver toxicity in Wistar albino rats as assessed by the biochemical changes and histopathological studies. The methanolic extract of aerial parts of Ageratum conyzoides afforded significant protection against CCl4 inducd hepatocellular injury.

1 , 1 , 2011